Palladium-catalyzed asymmetric dearomatization of naphthalene derivatives.
نویسندگان
چکیده
An intramolecular enantioselective metal-catalyzed dearomatization reaction is described. This procedure allows the dearomatization of naphthalene derivatives through an electrophilic aromatic substitution-type reaction on a Pd(II) intermediate. The high yields and enantioselectivities achieved make this procedure a valuable method for synthetic chemists.
منابع مشابه
DFT Studies on the Palladium-Catalyzed Dearomatization Reaction between Chloromethylnaphthalene and the Cyclic Amine Morpholine
Density functional theory calculations have been performed to investigate the mechanisms of the Pdcatalyzed dearomatization reaction between chloromethylnaphthalene and the cyclic amine morpholine. The calculation results indicate that the reductive elimination leading to the formation of the dearomatic product takes place via an intramolecular C−N bond coupling between the para carbon of an η-...
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ورودعنوان ژورنال:
- Journal of the American Chemical Society
دوره 131 19 شماره
صفحات -
تاریخ انتشار 2009